Generic Xenical

Product Name: Generic Xenical

Active Ingredients: Orlistat

Price: $1.05 per pill

Generic Xenical is a drug prescribed in the diagnosis of obesity or excessive weight. It helps to decrease weight preventing the fat deposits. It contains orlistat. The dosage is specified by a healthcare provider.

Order Medication

Generic Xenical is a specific inhibitor of gastrointestinal lipases with a long-lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine. Its effect consists in the formation of a covalent bond with the active serine region of the gastric and pancreatic lipases. In this case, an inactivated enzyme loses its ability to break down food fats in the form of triglycerides into absorbable free fatty acids and monoglycerides. Since undigested triglycerides are not absorbed, the resulting reduction in calorie intake leads to a decrease in body weight.

Drug indications

Long-term therapy of patients with obesity or patients with overweight, including having risk factors associated with obesity, in combination with a moderately hypocaloric diet;

In combination with hypoglycemic drugs (metformin, sulfonylurea derivatives and/or insulin) or a moderately hypocaloric diet in patients with type 2 diabetes mellitus who are overweight or obese.

Dosage and administration

Oral administration. Dosage regimen for adults – 1 capsule. (120 mg) with each meals intake (during, or no later than 1 hour after a meal). If you skip a meal or the food does not contain fat, then you can also skip a pill.

An increase in the dose of Xenical over the recommended (120 mg 3 times a day) does not lead to an increase in its therapeutic effect.D ose adjustment in elderly patients is not required. Dose adjustment for impaired liver or kidney function is not required. The safety and effectiveness of Xenical in children under the age of 18 has not been established.


In clinical studies in individuals with normal body weight and obese patients, single doses of 800 mg or multiple doses of 400 mg 3 times a day for 15 days were not accompanied by the appearance of significant side effects. In addition, there is experience with the use of Orlistat (the main component) at 240 mg 3 times a day for 6 months in obese patients, which was not accompanied by a significant increase in the frequency of adverse events.

Symptoms: in cases of overdose, either the absence of adverse events was reported, or adverse events did not differ from those observed when taking the drug in therapeutic doses.

Treatment: in case of severe Xenical overdose, it is recommended to monitor the patient for 24 hours.

According to studies in humans and animals, any systemic effects that could be associated with the lipase-inhibiting properties of orlistat should be quickly reversible.


  • Hypersensitivity to the drug or any other components contained in the capsule;
  • Chronic malabsorption syndrome;
  • Cholestasis.

Side effects

Side effects to Xenical occurred mainly from the gastrointestinal tract and were due to the pharmacological drug action, which prevents the absorption of food fats. Very often, phenomena such as oily secretions from the rectum, gas with a certain amount of secretions, imperative urges to defecate, steatorrhea, increased frequency of bowel movements, loose stools, flatulence, abdominal pain or discomfort were noted.

Their frequency magnifies with increasing fat content in the diet. Patients should be informed about the possibility of adverse reactions from the gastrointestinal tract and taught how to eliminate them by dieting, especially in relation to the amount of fat contained in it. The use of a low-fat diet reduces the chance of side effects of the gastrointestinal tract and thereby helps patients to control and regulate fat intake.

As a rule, these adverse reactions are mild and transient. They occurred in the early stages of treatment (in the first 3 months), and most patients had no more than one episode of such reactions.

When treating with Xenical, the following adverse events of the gastrointestinal tract often occur:

  • “soft” stools;
  • pain or discomfort in the rectum;
  • fecal incontinence;
  • bloating;
  • tooth damage;
  • gum disease.

There were also found the following side effects:

  • headaches;
  • upper respiratory tract infections;
  • flu;
  • lower respiratory tract infections;
  • urinary tract infections;
  • dysmenorrhea;
  • anxiety;
  • weakness.

In patients with type 2 diabetes mellitus, the nature and frequency of adverse events were comparable to those in individuals without diabetes with overweight and obesity. The only new side effects in patients with type 2 diabetes mellitus were hypoglycemic conditions that occurred with a frequency of> 2% and incidence of ≥1% compared with placebo (which could result from improved compensation for carbohydrate metabolism), and often bloating.

In a 4-year clinical study, the overall safety profile did not differ from that obtained in 1- and 2-year studies. At the same time, the overall frequency of adverse events from the gastrointestinal tract decreased annually during the 4-year period of taking the drug.

Pregnancy and lactation

Category B. In studies of reproductive toxicity in animals, no teratogenic and embryotoxic effects of the drug were observed. In the absence of a teratogenic effect in animals, a similar effect in humans should not be expected. However, due to the lack of clinical data, Xenical should not be prescribed to pregnant women.

Binding of orlistat with breast milk has not been studied, therefore, it should not be taken during breastfeeding.